Find the dominant constraint in your upstream process in 4 weeks.
We sit above your existing models, omics, and BI to force a decision: what is limiting under real process bounds, and what 3 to 5 experiments you run next.
Not dashboards. Not another omics tool. A fixed-scope diagnostic sprint.
- Identify the dominant constraint under real process bounds.
- Translate messy signals into 3 to 5 ranked experiments.
- Deliver a decision-ready diagnostic report in 4 weeks.
Meet Metastate
Metastate runs fixed-scope diagnostic sprints for upstream bioprocess teams. We deliver the clarity you need to move faster without overextending your engineering budget.
A compact engagement that finds the dominant constraint, maps the limiting mechanism, and defines what to test next.
You receive a ranked experiment roadmap plus annotated diagnostic evidence so your next steps are obvious.
Our team blends metabolic reasoning, data interpretation, and production strategy to match the rigor of an internal specialist team.
Diagnostic sprint timeline
We gather your data, models, and production context to build a precise diagnostic lens.
Flux, cofactor balance, and pathway performance diagnostics surface bottlenecks and missing reactions.
We deliver a prioritized experiment plan with clear reasoning, risk notes, and expected impact.
Who this is for
- Upstream PD leads in precision fermentation when scale-up is diverging and process bounds are real.
- Strain teams when titer plateaus and hypotheses are multiplying.
- CDMO tech transfer when timelines are brutal and the next experiment must be justified.
Not for you if
- You want a software platform license.
- You want generic pathway visualization.
- You want us to run your wet lab for you.
What we diagnose
We focus on the diagnostic gaps that slow teams down: missing reactions, inefficient flux, ambiguous signals, and unclear intervention points.
Pathway weakness detection
Uncover missing reactions, inefficient routes, and structural gaps that cap performance.
Targeted system analysis
Pinpoint limiting steps, cofactor issues, and precursor bottlenecks holding back output.
Unknowns clarified
Resolve unexplained metabolites, strange flux patterns, or contradictory data signals.
Flux & model insights
Map carbon flow and energy balance to expose systemic constraints and levers.
Actionable roadmap
Receive a structured, ranked plan of experiments with clear impact and rationale.
Production readiness
Align diagnostics with downstream fermentation and scale-up goals before you invest in full cycles.
What we need from you
You do not need perfect data. We start with the minimum needed to frame the constraint, then pull in accelerators if available.
Minimum to start
- Process context and bounds.
- Strain background and target product.
- Recent runs: titer, yield, productivity, key byproducts.
- What you already tried and what failed.
Optional accelerators
- Omics: metabolomics, transcriptomics, proteomics.
- Existing GEM/FBA models.
- Bioreactor time-series data.
What you get
Every sprint ends with a concrete package you can take straight into the lab and sprint planning.
- Diagnostic report. A system-level snapshot of constraints, gaps, and opportunity areas.
- Ranked experiment roadmap. Prioritized tests with expected impact and rationale.
- Model & data annotations. Clear explanations of flux insights, cofactor balance, and key sensitivities.
- Handoff session. Walkthrough with your team to align on next steps and risks.
Where it fits best
Reconcile scale-up divergence and process-bound constraints.
Identify why titers plateau and where to intervene next.
Create a decision-ready diagnostic plan before timelines slip.
News & updates
Selected milestones that support the diagnostic sprint.
Ready for a clear diagnostic?
Book a 15-minute diagnostic call. We will review your system, discuss data availability, and outline next steps.
Not ready to schedule?
Request a diagnostic brief. Share a few details and we will respond with the right diagnostic framing for your use case.
Typical response time: 1 to 2 business days.