How to Diagnose a Titer Plateau Before Running Another Expensive Round

A titer plateau is usually a decision problem first and an experimentation problem second. The expensive failure mode is launching another wide round without deciding what would count as meaningful movement.

Start by separating leading explanations into mutually useful buckets: transport or oxygen limitation, regulation or stress response, feed strategy mismatch, measurement ambiguity, or downstream interpretation errors.

Then define which 3 to 5 runs would actually discriminate between those buckets. If a proposed run cannot rule out an important alternative explanation, it is probably noise dressed up as activity.

This is where a decision memo matters. It forces the team to state what is most likely true, what is still unresolved, and what evidence would change the plan.

How to diagnose a titer plateau before running another expensive round